Comparative analysis of basal locomotor activity-related metabolic phenotypes between C57BL/6 mice and ICR mice substrains derived from three different sources / 한국실험동물학회지
Laboratory Animal Research
;
: 140-149, 2017.
Article
in English
| WPRIM
| ID: wpr-204550
ABSTRACT
Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish the metabolic phenotype of animal model to minimize spurious interpretations and ensure a level of accuracy and reliability adequate for experimental research. However, the metabolic phenotype-related analysis within rodent strains derived from different source is nonexistent, especially in C57BL/6Korl mice and KorlICR mice (a domestic mouse strain). To compare the physiological and metabolic phenotypes over a period of time, we utilized the C57BL/6 mice (C57BL/6Korl, AC57BL/6, and BC57BL/6) and ICR mice (KorlICR, AICR, and BICR) derived from three different sources. Our data showed that average body weight, body temperature, food intake, and water consumption have a similar tendency among the C57BL/6 and ICR groups, except for the higher body weight of C57BL/6Korl mice over a period of time. Moreover, some significant differences was observed in adipose tissue mass and adipocyte size among the groups, with a higher tendency of C57BL/6Korl mice and KorlICR mice. Most importantly, resting metabolic rate (RMR) serves as an approximation of the metabolic phenotype showed no significant difference among the groups of C57BL/6 mice and ICR mice, except for the lower oxygen uptake of C57BL/6Korl mice compare to the AC57BL/6 mice. Taken together, our data suggest that C57BL/6 mice and ICR mice derived from three different sources have an overall similar feature of physiological and metabolic phenotypes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Phenotype
/
Rodentia
/
Body Temperature
/
Body Weight
/
Adipose Tissue
/
Adipocytes
/
Models, Animal
/
Drinking
/
Eating
Limits:
Animals
Language:
English
Journal:
Laboratory Animal Research
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS