Comparison of humoral and cell-mediated immunity in three different C57BL/6N mouse substrains / 한국실험동물학회지
Laboratory Animal Research
;
: 132-139, 2017.
Article
in English
| WPRIM
| ID: wpr-204551
ABSTRACT
Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic properties of C57BL/6NKorl substrain were compared with those of two other C57BL/6N substrains. There were no significant differences between the C57BL/6NKorl and the two other C57BL/6N substrains in the histological structures of the thymus and spleen, which are immunologic organs containing T cell and B cells. In addition, flow cytometric analysis did not reveal any significant differences in the distribution of T and B cell populations of the three substrains. To evaluate cell-mediated immunity of T cells in the three different substrains, we treated isolated T cells from spleen with Con A. The T cells of C57BL/6NKorl showed Con A-dependent proliferation of T cells at lower cell number than those in T cells from the other two C57BL/6N substrains. B cell-mediated humoral immune responses were not significant different among the three substrains. Thus, the results of this study provide evidence that C57BL/6NKorl mice are similar to those two other C57BL/6N substrains in humoral immunity, but C57BL/6NKorl has stronger response in cell mediated immunity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spleen
/
Thymus Gland
/
B-Lymphocytes
/
T-Lymphocytes
/
Cell Count
/
Adaptive Immunity
/
Immunity, Humoral
/
Immunity, Cellular
/
Memory
Limits:
Animals
Language:
English
Journal:
Laboratory Animal Research
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS