Studies on familial of basophil histamine releasability / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 628-639, 1998.
Article
in Korean
| WPRIM
| ID: wpr-204960
ABSTRACT
BACKGROUND:
Bronchial asthma is a complex genetic disorder. Although serum IgE level and bronchial hyperresponsiveness are well known to be under genetic control, the influence of genetic factors on basophil releasability has been seldom studied.OBJECTIVE:
The present study was carried out to investigate whether genetic factors may influence the basophil histamine releasability. MATERIALS ANDMETHODS:
We studied 50 children, 32 with atopic asthma (AA) and 18 normal control (NC), and their parents. Suspensions of leukocytes were isolated and stimulated with Ca ionophore and anti-IgE antibody. Then, histamine in the supernatant was as-sayed by an automated fluorometric analyzer.RESULTS:
Among the probands, AA children had a significantly higher anti-IgE induced histamine release than NC children. In contrast, Ca ionophore-induced histamine release was similar between the two groups. Ca ionophore-induced or anti-IgE-induced histamine release was not significantly different between parents of AA children and those of NC children. However, the maximal histamine release by Ca ionophore in parents had a significant correlation with that of probands, whereas the values by anti-IgE were not correlated between probands and their parents.CONCLUSION:
We confirmed that basophils from patients with atopic asthma are characterized by a specific increase in IgE-mediated histamine release. The significant correlation of Ca ionophore-induced maximal histamine release between children and their parents suggests that genetic factors may play an important role in the control of non-IgE-mediated relessability from basophils.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parents
/
Asthma
/
Suspensions
/
Basophils
/
Immunoglobulin E
/
Histamine
/
Genetics
/
Histamine Release
/
Leukocytes
Limits:
Child
/
Humans
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
1998
Type:
Article
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