Ondansetron Reduces Postoperative Nausea and Vomiting after a Laparoscopic Cholecystectomy / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 365-369, 2005.
Article
in Korean
| WPRIM
| ID: wpr-205125
ABSTRACT
BACKGROUND:
The aim of the study was to evaluate the prophylactic effect of ondansetron on the postoperative nausea and vomiting (PONV) after a laparoscopic cholecystectomy (LC).METHODS:
In this prospective, randomized, double-blind, placebo-controlled study, 77 healthy female patients, who underwent a LC under general anesthesia using sevoflurane were investigated. Patients were randomly divided into two groups; the ondansetron group (n = 39) was administered 4 mg ondansetron, and the placebo group (n = 38) 2 ml of normal saline before the end of surgery. The incidence and severity of PONV, and the need for rescue antiemetics during the first 6 h and 24 h after surgery were evaluated.RESULTS:
The incidence of nausea in the ondansetron was significantly lower than in the placebo group during the 0-6 h (early nausea, P<0.05), but not in the 6-24 h (late nausea) postoperative period. However, the total incidence of nausea over the whole 24 h postoperative period was significantly lower in the ondansetron (36%) than in the placebo group (61%)(P<0.05), due to the low incidence of early nausea in the former. The incidence of vomiting was significantly lower in the ondansetron than in the placebo group during the 0-6 h and 6-24 h postoperative period. Therefore the total incidence of vomiting was significantly lower in the ondansetron (5%) than in the placebo group (46%)(P<0.001) over the whole 24 h postoperative period. The severity of nausea was also significantly lower in the ondansetron than in the placebo group.CONCLUSIONS:
Ondansetron significantly reduces the PONV in female patients undergoing a LC during the first 24 h after surgery, and has a greater anti-vomiting than anti-nausea effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Vomiting
/
Incidence
/
Prospective Studies
/
Ondansetron
/
Cholecystectomy, Laparoscopic
/
Postoperative Nausea and Vomiting
/
Anesthesia, General
/
Antiemetics
/
Nausea
Type of study:
Controlled clinical trial
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2005
Type:
Article
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