Central N omega-nitro-L-arginine Methyl Ester Does not Influence Lithium-induced c-Fos and Conditioned Taste Aversion
Yonsei Medical Journal
;
: 869-874, 2003.
Article
in English
| WPRIM
| ID: wpr-205361
ABSTRACT
LiCl at doses sufficient to induce conditioned taste aversion (CTA) causes c-Fos expression in the brain regions implicated in CTA formation. It has been reported that nitric oxide (NO) may play a role in CTA learning and LiCl increases both the synthesis and activity of NO synthase (NOS) in the brain. In this study, we examined the effect of central N omega-nitro-L- arginine methyl ester (L-NAME) on the brain c-Fos expression and CTA learning induced by lithium in rats. In the results, intracerebroventricular L-NAME given prior to lithium did not change either the lithium-induced CTA or c-Fos in the relevant brain regions. This suggests that the brain NO system may not be involved in the neuronal activation during lithium-induced CTA formation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Avoidance Learning
/
Taste
/
Brain
/
Immunohistochemistry
/
Proto-Oncogene Proteins c-fos
/
Rats, Sprague-Dawley
/
Conditioning, Psychological
/
NG-Nitroarginine Methyl Ester
/
Injections, Intraventricular
/
Lithium
Limits:
Animals
Language:
English
Journal:
Yonsei Medical Journal
Year:
2003
Type:
Article
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