Effect of xanthohumol on melanogenesis in B16 melanoma cells
Experimental & Molecular Medicine
;
: 313-319, 2008.
Article
in English
| WPRIM
| ID: wpr-205425
ABSTRACT
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin content was accompanied by reduced tyrosinase enzyme activity, protein and mRNA expression. The levels of tyrosinase-related protein 1 and 2 mRNAs were decreased by XH. XH also inhibited alpha-melanocyte stimulating hormone- or forskolin-induced increases in melanogenesis, suggesting an action on the cAMP-dependent melanogenic pathway. XH downregulated the protein and mRNA expression of microphthalmia-associated transcription factor (MITF), a master transcriptional regulator of key melanogenic enzymes. These results suggest that XH might act as a hypo-pigmenting agent through the downregulation of MITF in the cAMP-dependent melanogenic pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Propiophenones
/
Melanoma, Experimental
/
Colforsin
/
Alpha-MSH
/
Membrane Glycoproteins
/
Signal Transduction
/
Down-Regulation
/
Cell Line
/
Cell Survival
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2008
Type:
Article
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