A Case of Acute Myeloid Leukemia Developing after Treatment for Brucellosis with Pancytopenia
Laboratory Medicine Online
;
: 157-160, 2015.
Article
in Korean
| WPRIM
| ID: wpr-20543
ABSTRACT
Human brucellosis is an important zoonotic disease and has a wide clinical spectrum. Nonspecific hematologic abnormalities related to brucellosis are frequently found, but pancytopenia is uncommon. Malignant diseases have been infrequently reported as a rare cause of pancytopenia in patients with brucellosis. We describe a patient with brucellosis and pancytopenia who was later diagnosed with acute myeloid leukemia. A 71-yr-old man was admitted to a hospital with fever and pancytopenia. Brucella was cultured from blood, and the bone marrow findings were in accordance with brucellosis. The patient's clinical symptoms improved; however, he still showed pancytopenia after completion of medical treatment. After approximately 6 months, he was readmitted with pneumonia and pancytopenia. The second bone marrow examination revealed hypercellular marrow with increased number of blasts. The chromosome analysis showed 46,XY,trp(8)(q11.2q22)[8]/46,idem,del(7)(q22)[12]. The patient was diagnosed with acute myeloid leukemia with myelodysplasia-related changes. He refused further evaluation and therapy, and subsequently died while receiving conservative treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancytopenia
/
Pneumonia
/
Bone Marrow
/
Bone Marrow Examination
/
Brucella
/
Brucellosis
/
Leukemia, Myeloid, Acute
/
Zoonoses
/
Fever
Limits:
Humans
Language:
Korean
Journal:
Laboratory Medicine Online
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS