Hepcidin Level and Iron Parameters in Patients with Chronic Kidney Disease
Laboratory Medicine Online
;
: 149-156, 2015.
Article
in Korean
| WPRIM
| ID: wpr-20544
ABSTRACT
BACKGROUND:
Hepcidin, a key regulator of iron homeostasis, is associated with iron metabolism imbalance in patients with chronic kidney disease (CKD). However, serum hepcidin level in anemic patients with CKD presents a contradictory picture. We investigated the relationship between serum hepcidin-25 level and iron parameters in patients with CKD.METHODS:
We defined and categorized patients with CKD according to the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines. We analyzed the relationship between serum hepcidin-25 level and iron parameters [serum iron, total iron-binding capacity (TIBC), unbound iron-binding capacity (UIBC), transferrin saturation, and ferritin levels] according to the CKD stage and clinical and laboratory characteristics.RESULTS:
Hb level, TIBC, and UIBC decreased and ferritin level increased (Ptrend0.05).CONCLUSIONS:
Serum hepcidin-25 level was not found to be associated with iron parameters or clinical status of CKD patients in our study. Determination of hepcidin-25 levels may not provide more information than conventional iron parameters in monitoring iron metabolism in CKD patients. However, further studies are needed to establish the clinical utility of hepcidin measurement in CKD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transferrin
/
Renal Insufficiency, Chronic
/
Ferritins
/
Hepcidins
/
Homeostasis
/
Anemia
/
Iron
/
Kidney
/
Kidney Diseases
/
Metabolism
Type of study:
Practice guideline
Limits:
Humans
Language:
Korean
Journal:
Laboratory Medicine Online
Year:
2015
Type:
Article
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