Factors Associated with Airway Disease and Interstitial Lung Disease in Rheumatoid Arthritis
Journal of Rheumatic Diseases
;
: 101-108, 2016.
Article
in Korean
| WPRIM
| ID: wpr-205475
ABSTRACT
OBJECTIVE:
This study examined lung involvement in patients with rheumatoid arthritis (RA) and identified factors associated with airway disease (AD) and interstitial lung disease (ILD).METHODS:
A total of 507 RA patients were enrolled in a cross-sectional study. Lung involvement was assessed by high-resolution computed tomography scan. The patient groups were classified according to normal, AD, and ILD. Multinomial logistic regression analysis was performed to identify factors associated with AD and ILD.RESULTS:
The most frequent lung involvement was AD (38.3%) followed by ILD (12.6%). Old age (adjust odds ratio [aOR] 2.58, 95% confidence interval [CI] 1.70 to 3.90 for AD; aOR 4.38, 95% CI 2.30 to 8.35 for ILD), male gender (aOR 2.57, 95% CI 1.22 to 5.42 for AD; aOR 5.48, 95% CI 2.20 to 13.65 for ILD) were factors associated with AD and ILD in RA patients. ILD was associated with short disease duration (aOR 0.30, 95% CI 0.14 to 0.62), AD was associated with high titers of anti-cyclic citrullinated peptides antibodies (anti-CCP; aOR 1.61, 95% CI 1.07 to 2.44).CONCLUSION:
AD was the most frequent lung involvement in patients with RA. Old age and male gender were both associated with AD and ILD. Short disease duration was associated with ILD. High titers of anti-CCP was associated with AD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Arthritis, Rheumatoid
/
Tomography, X-Ray Computed
/
Logistic Models
/
Odds Ratio
/
Cross-Sectional Studies
/
Risk Factors
/
Lung Diseases, Interstitial
/
Lung
/
Lung Diseases, Obstructive
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of Rheumatic Diseases
Year:
2016
Type:
Article
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