ADAM33 Polymorphisms Are Associated with Susceptibility to Systemic Lupus Erythematosus in a Korean Population
Journal of Rheumatic Diseases
; : 88-95, 2016.
Article
in En
| WPRIM
| ID: wpr-205477
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: The objective of this study is to assess whether genetic functional variants of disintegrin and metalloprotease 33 (ADAM33) are associated with susceptibility to systemic lupus erythematosus (SLE) in a Korean population. METHODS: We previously identified 48 single nucleotide polymorphisms (SNPs) in ADAM33. Six SNPs were selected with regard to the linkage disequilibrium pattern. An association study of ADAM33 was conducted in 190 patients with SLE and 469 control subjects. SNPs were genotyped using the TaqMan Real-time polymerase chain reaction method, and haplotype analyses of related variants were performed. RESULTS: All SNPs were in Hardy-Weinberg equilibrium. Significant associations were found between the ADAM33 polymorphisms and SLE at rs2787094 (adjusted odds ratio [OR] 1.88, 95% confidence interval [CI] 1.00 to 3.54; p<0.0001). The rs554743 polymorphism was associated with the presence of the immunoglobulin M anti-cardiolipin antibody (adjusted OR 0.29, 95% CI 0.10 to 0.83; p=0.021). CONCLUSION: ADAM33 polymorphisms were associated with susceptibility to SLE and development of clinical disease manifestations in a Korean population. Further study is warranted to clarify the role of ADAM33 in SLE pathogenesis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Haplotypes
/
Immunoglobulin M
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Linkage Disequilibrium
/
Odds Ratio
/
Polymorphism, Single Nucleotide
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Real-Time Polymerase Chain Reaction
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Lupus Erythematosus, Systemic
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Journal of Rheumatic Diseases
Year:
2016
Type:
Article