Kikuchi-Fujimoto Disease, A Possible Complication of Rituximab Treatment
Journal of the Korean Society of Pediatric Nephrology
;
: 138-141, 2012.
Article
in English
| WPRIM
| ID: wpr-205537
ABSTRACT
Rituximab, a chimeric anti-CD20 IgG1 monoclonal antibody, has been used as a rescue therapy for steroid-dependent or refractory nephrotic syndrome. However, the adverse effects of rituximab are yet to be investigated. We report a case of a 9-year-old boy with steroid-dependent nephrotic syndrome who developed Kikuchi-Fujimoto disease after several cycles of rituximab therapy. Kikuchi-Fujimoto disease is a benign, self-limited necrotizing histiocytic lymphadenitis of unknown etiology. In the present case, Kikuchi-Fujimoto disease developed when the peripheral blood B-cell count of the patient was at nadir, and the lesion regressed slowly but spontaneously after recovery of the B-cell count. To our knowledge, although the pathologic diagnosis of Kikuchi-Fujimoto disease was unavailable, this is the first report of Kikuchi-Fujimoto disease with clinical diagnosis as a possible adverse effect of rituximab.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunoglobulin G
/
B-Lymphocytes
/
Histiocytic Necrotizing Lymphadenitis
/
Antibodies, Monoclonal, Murine-Derived
/
Rituximab
/
Lymphadenitis
/
Nephrotic Syndrome
Limits:
Child
/
Humans
Language:
English
Journal:
Journal of the Korean Society of Pediatric Nephrology
Year:
2012
Type:
Article
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