Two Cases of Epidermolysis Bullosa Simplex (Dowling-Meara Type) / 대한피부과학회지
Korean Journal of Dermatology
;
: 955-960, 2000.
Article
in Korean
| WPRIM
| ID: wpr-205603
ABSTRACT
The Dowling-Meara type of epidermolysis bullosa simplex is a rare genodermatosis transmitted by autosomal dominant pattern. It starts during the first 3 months of life and is characterized by generalized bullae in a herpetiform pattern. We report two cases of Dowling-Meara type of epidermolysis bullosa simplex. The first case is an 18-year-old male patient who showed bullae in a herpetiform arrangement on the dorsa of both hands, forearms, and trunk, hyperkeratosis on the palms and soles, postinflammatory hypo- and hyperpigmentations, and dystrophy of finger and toe nails. The second case is a 1-month-old boy who showed multiple bullae in a herpetiform and confluent arrangement scattered on the whole body, particularly on the dorsa of both feet and hands. Microscopically and electro-microscopically, two cases all showed intraepidermal blisters formed within the basal keratinocyte in association with clumping of the tonofilaments and cytolysis of the basal cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Intermediate Filaments
/
Toes
/
Keratinocytes
/
Epidermolysis Bullosa Simplex
/
Blister
/
Epidermolysis Bullosa
/
Fingers
/
Foot
/
Forearm
/
Hand
Limits:
Adolescent
/
Humans
/
Male
/
Infant, Newborn
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2000
Type:
Article
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