The Aortic Reactivity to Nitric Oxide after Cardiopulmonary Bypass in Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 463-467, 2006.
Article
in Korean
| WPRIM
| ID: wpr-205606
ABSTRACT
BACKGROUND:
We evaluated whether vessel reactivity to nitric oxide changed after cardiopulmonary bypass, which would play an inportant role in temporary vital organ perfusion.METHODS:
We used the distal aortas of five rats weighing 400-500 g after cardiopulmonary bypass in experimental group. We also used the distal aortas of five rats before cardiopulmonary bypass under sham operation in control group. All cumulative concentration-effect curves were performed in the aortic rings and EC50 and maximal response (Emax) were calculated by using nonlineal logistic regression analysis with the software PRISM (Graphpad, Mountain View, CA).RESULTS:
CPB inhibited acetylcholine induced relaxation in aortic rings and also inhibited sodium nitroprusside (SNP) induced relaxation in ones. It was similar to depression of acetylcholine induced relaxation.CONCLUSIONS:
The depression of aortic rings relaxation after CPB may be associated with attenuated sensitivity of them to NO in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta
/
Perfusion
/
Relaxation
/
Nitroprusside
/
Cardiopulmonary Bypass
/
Acetylcholine
/
Logistic Models
/
Depression
/
Nitric Oxide
Type of study:
Risk factors
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2006
Type:
Article
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