Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis
Yonsei Medical Journal
;
: 776-783, 2016.
Article
in English
| WPRIM
| ID: wpr-205736
ABSTRACT
PURPOSE:
Many epidemiological studies have investigated environmental risk factors for the development of acoustic neuroma. However, these results are controversial. We conducted a meta-analysis of case-control studies to identify any potential relationship between history of noise exposure, smoking, allergic diseases, and risk of acoustic neuroma. MATERIALS ANDMETHODS:
We searched PubMed to identify relevant articles. Two researchers evaluated the eligibility and extracted the data independently.RESULTS:
Eleven case-control studies were included in our meta-analysis. Acoustic neuroma was found to be associated with leisure noise exposure [odds ratio (OR)=1.33, 95% confidence interval (CI) 1.05-1.68], but not with occupational noise exposure and ever noise exposure (OR=1.20, 95% CI 0.84-1.72 and OR=1.15, 95% CI 0.80-1.65). The OR of acoustic neuroma for ever (versus never) smoking was 0.53 (95% CI 0.30-0.94), while the subgroup analysis indicated ORs of 0.95 (95% CI 0.81-1.10) and 0.49 (95% CI 0.41-0.59) for ex-smoker and current smoker respectively. The ORs for asthma, eczema, and seasonal rhinitis were 0.98 (95% CI 0.80-1.18), 0.91 (95% CI 0.76-1.09), and 1.52 (95% CI 0.90-2.54), respectively.CONCLUSION:
Our meta-analysis is suggestive of an elevated risk of acoustic neuroma among individuals who were ever exposed to leisure noise, but not to occupational noise. Our study also indicated a lower acoustic neuroma risk among ever and current cigarette smokers than never smokers, while there was no significant relationship for ex-smokers. No significant associations were found between acoustic neuroma and history of any allergic diseases, such as asthma, eczema, and seasonal rhinitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Smoking
/
Neuroma, Acoustic
/
Risk Factors
/
Occupational Exposure
/
Environmental Exposure
/
Hypersensitivity
/
Leisure Activities
/
Noise
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2016
Type:
Article
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