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Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 1420-1428, 2016.
Article in English | WPRIM | ID: wpr-205894
ABSTRACT

PURPOSE:

This study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase CINV prophylaxis in the Korean population subset of the Pan Australasian Chemotherapy Induced Emesis burden of illness (PrACTICE) study. MATERIALS AND

METHODS:

This subgroup analysis evaluated 158 Korean patients receiving HEC or MEC and compared the data (wherever possible) with that of 648 patients from the Asia-Pacific (AP) region. Study endpoints included evaluation of primary CINV prophylaxis and adherence to acute-phase CINV prophylaxis in cycle 1 (American Society of Clinical Oncology [ASCO] Quality Oncology Practice Initiative [QOPI]).

RESULTS:

In South Korea and the AP, a 5-hydroxytryptamine-3 receptor antagonist (5HT₃-RA) prophylaxis for the acute phase was administered to 79/80 patients (98.8%) for HEC and 70/71 patients (98.6%) for MEC regimens (QOPI-1). Triple regimen (corticosteroid–5HT₃-RA–neurokinin 1-RA) was initiated in 46/80 patients (57.5%) for prophylaxis of acute CINV in cycle 1 of HEC (QOPI-3). Double regimen (corticosteroid–5HT₃-RA, with or within NK₁-RA) was initiated in 61/71 patients (83.1%) for control of acute CINV in cycle 1 of MEC a(QOPI-2).

CONCLUSION:

Active management of CINV is necessary in cycle 1 of HEC in South Korea, despite higher rates than the AP region. Adherence to the international guidelines for CINV prophylaxis requires attention in the acute phase in cycle 1 of the HEC regimen.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Vomiting / Cost of Illness / Receptors, Serotonin, 5-HT3 / Drug Therapy / Korea / Medical Oncology / Antiemetics / Nausea Type of study: Practice guideline Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vomiting / Cost of Illness / Receptors, Serotonin, 5-HT3 / Drug Therapy / Korea / Medical Oncology / Antiemetics / Nausea Type of study: Practice guideline Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2016 Type: Article