Analysis of Plasma Long-Chain Fatty Acids in Hypertensive Patients
Journal of Korean Society for Clinical Pharmacology and Therapeutics
;
: 166-179, 2011.
Article
in Korean
| WPRIM
| ID: wpr-206105
ABSTRACT
BACKGROUND:
Numerous studies have suggested that polyunsaturated fatty acids (PUFAs)-supplemented diets may decrease cardiovascular morbidity and mortality. Especially, omega-3 PUFAs may exert beneficial effects to the treatment and prevention of dyslipidemias, arrhythmias, atherosclerosis, and hypertension.METHODS:
This study investigated plasma lipid profiles including total cholesterol, triglycerides (TG), LDL, HDL, and antioxidant status indicative of vitamin A, vitamin E, malondialdehyde (MDA) and distribution of plasma long-chain fatty acids (C12-C24) in 28 normal subjects and 24 hypertensive patients. Also, the correlation among PUFAs, levels of antioxidant status, and lipid profiles of the subjects were estimated.RESULTS:
The distribution of omega-3 PUFAs, saturated fatty acids, and monounsaturated fatty acids showed significant differences (P<0.05), but that of omega-6 PUFAs did not exhibit significant differences. The omega-6/omega-3 ratio exhibited 36.96 in normal group and 14.29 in the hypertensive patient group. The levels of vitamin A, vitamin E, and MDA were increased significantly in the hypertensive patient group.CONCLUSION:
PUFA levels were estimated in the hypertensive patients and normal group. The results suggest that dietary intake of proper omega-6/omega-3 ratio is needed for prevention and treatment of hypertension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Arrhythmias, Cardiac
/
Triglycerides
/
Vitamin A
/
Vitamin E
/
Vitamins
/
Fatty Acids, Monounsaturated
/
Cholesterol
/
Diet
/
Atherosclerosis
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Society for Clinical Pharmacology and Therapeutics
Year:
2011
Type:
Article
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