The Effect of Basic Fibroblast Growth Factor on the Vascularization of Porous Polyethylene Orbital Implant(Medpor(R))
Journal of the Korean Ophthalmological Society
;
: 2258-2264, 2002.
Article
in Korean
| WPRIM
| ID: wpr-20614
ABSTRACT
PURPOSE:
We investigated the effect of basic fibroblast growth factor (bFGF) on the vascularization rate of Medpor(R), a synthetic polyethylene orbital implant.METHODS:
Medpor(R), pretreated or untreated with bFGF (25 ng/ml), was inserted into one eye of 18 New Zealand white rabbits and removed at 1, 2, and 4 weeks after implantation, and stained with hematoxylineosin and Masson's trichrome. Degree of vascularization was classified into zone 1 (or=4.6 mm ingrowth).RESULTS:
One and two weeks after implantation, the percentage of the vascularization area were 56.25% and 68.75% in bFGF-untreated group, while those of bGFG-treated group were 75% and 80.56% respectively, but there were no statistical difference between bFGF-untreated and treated group. However, four weeks after implantation it was significantly higher in bFGF-treated group (84.38%) than in bFGFuntreated group (66.25%) (P<0.05).CONCLUSIONS:
BFGF enhanced more and early fibrovascular ingrowth of Medpor(R).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orbit
/
Fibroblast Growth Factor 2
/
Orbital Implants
/
Polyethylene
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2002
Type:
Article
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