Study on evaluation of a schedule for treatment of malaria in children and adult based upon some pharmacokinetic parameters and clinical effects

ABSTRACT

A compartment model with separate pharmacokinetic estimates for children and adults was found best to describe the disposition of artemisinin after oral administration. The popular estimates for artemisinin half life and clearance and distribution volume were found for both age groups. The concentration was estimated decrease from day 1 to day 5, a value found to be similar for children and adults. Clinical efficacy, in terms of parasite clearance and fever subsidence times, was comparable between children and adults no difference