Involvement of MAP Kinases in Apoptosis of Macrophage Treated with Trichomonas vaginalis
Yonsei Medical Journal
;
: 751-754, 2004.
Article
in English
| WPRIM
| ID: wpr-206344
ABSTRACT
A primitive protozoan parasite Trichomonas vaginalis selectively activates the signal transduction pathways in macrophages (RAW264.7). This study evaluated the correlation of these signaling pathways and T. vaginalis-induced cell apoptosis. In macrophages infected with T. vaginalis, apoptosis was assessed on the basis of DNA fragmentation on agarose gel electrophoresis. Infection of macrophages with T. vaginalis induced tyrosine phosphorylation of several proteins. Infected cells with T. vaginalis were shown to associate with phosphorylation of the extracellular signal-regulated (ERK) 1/2 kinase, p38, c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases on Western blot analysis. The present finding also demonstrated a link between the ERK1/2, JNK and p38 apoptotic pathways that was modulated by T. vaginalis infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Trichomonas Infections
/
Trichomonas vaginalis
/
Apoptosis
/
Mitogen-Activated Protein Kinases
/
MAP Kinase Signaling System
/
Macrophages
Limits:
Animals
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2004
Type:
Article
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