Bioavailability of EVA-Coated Metallic Stents Implanted in the Rabbit Iliac Artery
Korean Circulation Journal
;
: 614-619, 2003.
Article
in Korean
| WPRIM
| ID: wpr-206595
ABSTRACT
BACKGROUND AND OBJECTIVES:
Coronary artery stenting actually shows a high efficacy in the treatment of coronary heart disease, but has the major limitation of restenosis. The ethylene-vinyl acetate copolymer (EVA), a biocompatible nondegradable copolymer, has been employed as a rate-controlling membrane in several drug delivery systems. Herein, the feasibility of an EVA-coated coronary stent was evaluated as a possible route for localized drug delivery. MATERIALS ANDMETHODS:
A total of 15 rabbits were employed in this study. An uncoated stent was implanted into the non-diseased iliac artery in six rabbits, and an EVA-coated stent into a further nine. On the 30th day following the stent implantations, stented segments of the iliac arteries were removed for histological processing and morphometric analysis.RESULTS:
The mean neointimal area of the uncoated and coated groups were 1.009 and 1.011 mm2 (p=0.56), respectively. No inflammatory cells were found in coated group. There were no apparent differences between the two groups.CONCLUSION:
The results from this study have demonstrated that an EVA-coated coronary stent might be an appropriate method for the controlled-release of a drug.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyvinyls
/
Biological Availability
/
Stents
/
Drug Delivery Systems
/
Coronary Disease
/
Coronary Vessels
/
Iliac Artery
/
Membranes
Limits:
Animals
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2003
Type:
Article
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