The Long-Term Clinical Outcomes of Low Molecular Weight Heparin Combined with Platelet Glycoprotein IIb/IIIa Inhibitor in Patients with Acute Coronary Syndrome
Korean Circulation Journal
;
: 559-567, 2003.
Article
in Korean
| WPRIM
| ID: wpr-206602
ABSTRACT
BACKGROUND AND OBJECTIVES:
Platelet activation and aggregation, with resultant arterial thrombus formation, play pivotal roles in the pathophysiology of acute coronary syndrome (ACS). The efficacy of tirofiban, a specific inhibitor of the platelet glycoprotein IIb/IIIa receptor, combined with heparin, or low molecular heparin (LMWH), in the management of ACS were evaluated. SUBJECTS AND MEHTODS One hundred seventeen patients (60.8+/-10.9 years, 76 male), with unstable angina or non-ST elevation myocardial infarction, who had ST-T changes and elevated troponin, were divided into 4 groups Group I (n=30 heparin alone), Group II (n=28 LMWH, dalteparin alone), Group III (n=29 tirofiban combined with heparin) and Group IV (n=30 tirofiban with LMWH). The major adverse cardiac events (MACE) among the 4 groups, during 6-month clinical follow-ups, were compared.RESULTS:
Percutaneous coronary intervention, or a coronary artery bypass graft, was performed in 23, 19, 19 and 22 patients from Groups I, II, III and IV, respectively (p=0.87). A minor bleeding complication developed in 2 (6.7%), 1 (3.6%), 1 (3.4%) and 2 patients (6.7%) in groups I, II, III and IV, respectively (p=0.79). During the six-month follow-up MACE occurred in 7 (30.4%), 6 (31.6%), 3 (15.8%) and 4 patients (18.2%) in groups I, II, III and IV, respectively (p=0.02 Group I and II vs. Group III and IV).CONCLUSION:
Tirofiban combined with LMWH is safe and may improve the long-term prognosis of patients with ACS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Thrombosis
/
Troponin
/
Blood Platelets
/
Glycoproteins
/
Heparin
/
Platelet Activation
/
Coronary Artery Bypass
/
Follow-Up Studies
/
Angioplasty
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2003
Type:
Article
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