Cellular Plexiform Fibrohistiocytic Tumor / 대한피부과학회지
Korean Journal of Dermatology
;
: 396-399, 2015.
Article
in Korean
| WPRIM
| ID: wpr-206791
ABSTRACT
Plexiform fibrohistiocytic tumor (PFHT) is a rare mesenchymal neoplasm of intermediate malignancy and possibly of myofibroblast origin. It is morphologically divided into 3 groups cellular, fibrous, and mixed. A 4-year-old girl presented with an irregular shaped subcutaneous mass on her left popliteal fossa for 6 months. The biopsy specimen showed multinodular tumor islands extending from dermis to subcutaneous layer, composed of histiocytes and osteoclast-like multinucleated giant cells, and circumscribed by fibrous tissue. Immunohistochemical staining was positive for CD68 in giant cells and histiocyte-like cells within tumor islands and faintly positive for smooth muscle actin around nodules. A cellular variant of PFHT was eventually diagnosed. Although PFHT comprises morphologically normal cells, it has the biological potential for malignant change and distal metastasis. Therefore, PFHT is categorized as a neoplasm of intermediate malignancy, and wide total excision with close follow-up is crucial.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Giant Cells
/
Actins
/
Dermis
/
Myofibroblasts
/
Islands
/
Histiocytes
/
Muscle, Smooth
/
Neoplasm Metastasis
Limits:
Child, preschool
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2015
Type:
Article
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