Cost-Effectiveness of Recombinant Tissue Plasminogen Activator in the Management of Acute Ischemic Stroke: A Systematic Review
Journal of Clinical Neurology
;
: 117-126, 2010.
Article
in English
| WPRIM
| ID: wpr-207098
ABSTRACT
BACKGROUND AND PURPOSE:
This work was undertaken to review the current cost-effectiveness analysis data on thrombolysis by intravenous (IV) therapy with recombinant tissue plasminogen activator (rtPA) for acute ischemic stroke.METHODS:
PubMed was searched for articles published between 1995 and 2008. The cost-effectiveness analysis data from eight eligible studies were reviewed, paying particular attention to their modeling assumptions and the quality of the source data.RESULTS:
The reviewed studies were from six countries USA (n=2), UK (n=2), Canada (n=1), Australia (n=1), Spain (n=1), and Denmark (n=1); most were performed from the healthcare-system and/or societal perspectives. IV rtPA was associated with an acceptable increase in short-term cost [range US$ 36-236/patient; US$ 29,148-55,591/quality-adjusted life-years (QALYs)], and a net long-term cost saving that was higher from a societal perspective (range -US$ 12,043 to -US$ 630/patient; -US$ 207,253 to -US$ 21,938/QALYs) than from a healthcare-system perspective (range -US$ 5,811 to -US$ 5,415/patient; -US$ 41,137 to -US$ 4,662/QALYs).CONCLUSIONS:
IV rtPA seems to be a cost-effective strategy for the management of acute ischemic stroke, and might reduce the associated healthcare costs as well as patients' disabilities. Further cost-effectiveness research and the development of a public health strategy are warranted to optimize the use of rtPA in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Australia
/
Spain
/
Canada
/
Public Health
/
Health Care Costs
/
Cost Savings
/
Tissue Plasminogen Activator
/
Stroke
/
Denmark
/
Korea
Type of study:
Health economic evaluation
/
Prognostic study
/
Systematic reviews
Country/Region as subject:
North America
/
Asia
/
Europa
/
Oceania
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2010
Type:
Article
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