Acquisition of methicillin resistance and progression of multiantibiotic resistance in methicillin-resistant Staphylococcus aureus
Yonsei Medical Journal
;
: 526-533, 1998.
Article
in English
| WPRIM
| ID: wpr-207247
ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) produces specific penicillin-binding protein, PBP2', which shows remarkably low affinities to most beta-lactam antibiotics except those such as penicillin G and ampicillin. The region surrounding mecA has been called additional DNA or mec and is thought to be of extraspecies origin. From the study of mec, we found that mec is a novel mobile genetic element and designated as staphylococcal cassette chromosome mec (SCCmec). There are three types of SCCmec. In the past decades, MRSA has become resistant to many antibiotics, such as carbapenems, new quinolones, and minocycline etc. It seems to be a characteristic of MRSA to acquire multi-resistance by accumulating multiple resistance genes around the mecA gene inside SCCmec.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Staphylococcus aureus
/
Drug Resistance, Microbial
/
Methicillin Resistance
/
Drug Resistance, Multiple
Language:
English
Journal:
Yonsei Medical Journal
Year:
1998
Type:
Article
Similar
MEDLINE
...
LILACS
LIS