Plasmid-encoded AmpC beta-lactamases: how far have we gone 10 years after the discovery?
Yonsei Medical Journal
;
: 520-525, 1998.
Article
in English
| WPRIM
| ID: wpr-207248
ABSTRACT
The dogma that ampC genes are located exclusively on the chromosome was dominant until about 10 years ago. Since 1989 over 15 different plasmid-encoded AmpC beta-lactamases have been reported from several countries. Most of these enzymes evolved in two clusters. The major cluster includes several enzymes with a high similarity to CMY-2, which is the closest related chromosomal AmpC enzyme of Citrobacter freundii. A second cluster centers around CMY-1. It is less homogeneous and not closely related chromosomal AmpC enzymes. Molecular diversification by amino acid substitutions does not usually translate into a change in the resistance phenotype. At this time, CMY-2 appears to be the most prevalent and widely distributed. Further global increase of prevalence and diversity of plasmidic AmpC beta-lactamases have to be anticipated in the next millenium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasmids
/
Structure-Activity Relationship
/
Beta-Lactamases
/
Tissue Distribution
/
Microbiology
Language:
English
Journal:
Yonsei Medical Journal
Year:
1998
Type:
Article
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