Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents
Biomolecules & Therapeutics
;
: 67-74, 2016.
Article
in English
| WPRIM
| ID: wpr-20736
ABSTRACT
In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O-beta-D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL-1beta-treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Administration, Oral
/
Interleukin-6
/
Macrophages, Alveolar
/
Lignans
/
Eleutherococcus
/
Epithelial Cells
/
Acute Lung Injury
/
Lung
/
Macrophages
Limits:
Animals
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS