Success Rate of Microsurgical Multiple Testicular Sperm Extraction and Sperm Presence in the Ejaculate in Korean Men With Y Chromosome Microdeletions
Korean Journal of Urology
;
: 536-540, 2013.
Article
in English
| WPRIM
| ID: wpr-207546
ABSTRACT
PURPOSE:
We assessed the frequency of azoospermia factor a (AZFa), AZFb, and AZFc deletions and examined correlations between the deletion sites and the success rates of sperm presence within the ejaculate and surgical sperm retrieval in Korean men. MATERIALS ANDMETHODS:
A total of 1,919 azoospermic and severely oligozoospermic men were assessed for Y chromosome microdeletions. Among them, 168 men with AZF deletions were identified and their medical records were reviewed.RESULTS:
Of the total 168 men with AZF deletions, there were 13 with AZFa, 10 with AZFb, 95 with AZFc, 37 with AZFbc, and 13 with AZFabc deletions. Of the 95 men with isolated AZFc deletion, 51 had the presence of sperm in the ejaculate. Of the infertile men with any other deletion, however, only two patients (one man with AZFb deletion and another with AZFbc deletion) showed the presence of sperm in the ejaculate. The success rates for surgical sperm retrieval were 7.1% (1/14) in men with AZFbc deletion and 54.8% (17/31) in the isolated AZFc deletion group. No sperm was obtained from the patients with AZFa or AZFb deletions who underwent microsurgical sperm retrieval. In the isolated AZFc deletion group, there were significant differences between azoospermic and severely oligozoospermic patients in terms of testicular volume and serum levels of follicle-stimulating hormone and luteinizing hormone, whereas no significant differences were found when the group was divided by surgical sperm retrieval outcomes.CONCLUSIONS:
Deletions of the AZFa and AZFb regions are associated with severe spermatogenetic impairment. However, more than half of men with an AZFc deletion had sperm within the ejaculate or testis for in vitro fertilization with intracytoplasmic sperm injection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sex Chromosome Aberrations
/
Spermatozoa
/
Testis
/
Vitamin B 12
/
Y Chromosome
/
Luteinizing Hormone
/
Fertilization in Vitro
/
Medical Records
/
Chromosome Deletion
/
Sperm Injections, Intracytoplasmic
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Korean Journal of Urology
Year:
2013
Type:
Article
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