Cerebral Venous Sinus Thrombosis Associated with Antithrombin III Deficiency: A Case Report

ABSTRACT

Antithrombin III deficient individuals have an increased risk of venous thrombosis and thromboembolism at a young age. To our knowledge, cerebral venous thrombosis associated with antithrombin III deficiency has not yet been reported in Korea. A 27-year-old pregnant woman without any known stroke risk factors was admitted to our hospital because of convulsions. Brain MRI and MR venography showed dural sinus thrombosis of the superior sagittal sinus, straight sinus, and left lateral sinus with venous hemorrhagic infarctions in both frontal and parietal lobes. Antithrombin III concentrations were decreased to 37%. We speculated that the etiology of the cerebral venous thrombosis in this patient was associated with antithrombin III deficiency. We suggest that antithrombin III deficiency should be considered as a possible cause of cerebral venous thrombosis.