Polysaccharides isolated from Phellinus gilvus enhances dermal wound healing in streptozotocin-induced diabetic rats
Journal of Veterinary Science
;
: 161-164, 2005.
Article
in English
| WPRIM
| ID: wpr-207850
ABSTRACT
Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization, granulation tissue, and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus, Phellinus gilvus (PG) have various anti-inflammatory activities. In present study, we have assessed the effect of polysaccharides from PG on the dermal wound healing of polysaccharides from PG in streptozotocin-induced diabetic rat model. Six of 6-mm circular wounds were created with biopsy punch on the 4th day after induction of diabetes. After 24 hours, each test substance was applied to the wound twice a day for next 5 days. Circular wounds treated with PG showed significantly reduced wound contraction and complete reepithelialization, as compared to wounds of non-treated (p < 0.05). These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing, and could be developed as a wound healing agent in such clinical settings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polysaccharides
/
Skin
/
Basidiomycota
/
Wound Healing
/
Wounds, Penetrating
/
Administration, Cutaneous
/
Rats, Sprague-Dawley
/
Streptozocin
/
Diabetes Mellitus, Experimental
/
Histocytochemistry
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2005
Type:
Article
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