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Follow-up Testing of Interferon-Gamma Release Assays Are Useful in Ankylosing Spondylitis Patients Receiving Anti-Tumor Necrosis Factor Alpha for Latent Tuberculosis Infection
Journal of Korean Medical Science ; : 1090-1093, 2014.
Article in English | WPRIM | ID: wpr-208223
ABSTRACT
We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNFalpha). The study participants (n=127) had a negative IGRA screening before receiving anti-TNFalpha and were evaluated by follow-up IGRA. We retrospectively examined data of the subjects according to age, gender, tuberculosis prophylaxis, concomitant medications, IGRA conversion and anti-TNFalpha, including type and treatment duration. The median duration of anti-TNFalpha was 21.5 months, and the median age was 35.3 yr. Of the 127 patients, IGRA conversion was found in 10 patients (7.9%). There was no significant variation between IGRA conversion rate and any risk factors except for age. IGRA conversion rate was not significantly different between AS and rheumatoid arthritis (P=0.12). IGRA conversion was observed in AS patients receiving anti-TNFalpha in Korea. A follow-up IGRA test can be helpful for identifying LTBI or new tuberculosis in AS patients receiving anti-TNFalpha.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Spondylitis, Ankylosing / Reproducibility of Results / Follow-Up Studies / Longitudinal Studies / Sensitivity and Specificity / Interferon-gamma / Tumor Necrosis Factor-alpha / Treatment Outcome / Antirheumatic Agents Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Spondylitis, Ankylosing / Reproducibility of Results / Follow-Up Studies / Longitudinal Studies / Sensitivity and Specificity / Interferon-gamma / Tumor Necrosis Factor-alpha / Treatment Outcome / Antirheumatic Agents Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2014 Type: Article