Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes
Journal of Korean Medical Science
;
: 1038-1041, 2014.
Article
in English
| WPRIM
| ID: wpr-208230
ABSTRACT
The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease, and type 2 diabetes will be discussed, focusing on the role of specific innate immune receptors involved in these disease processes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreas
/
Cytokines
/
Models, Immunological
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
/
Inflammasomes
/
Immunity, Innate
Type of study:
Etiology study
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2014
Type:
Article
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