Polymorphism of the Ciliary Neurotrophic Factor (CNTF) Gene in Korean / 체질인류학회지

ABSTRACT

Ciliary neurotrophic factor (CNTF) is one of the important factors in neuronal survival. Mutation in CNTF gene was found first in Japanese. We analyzed the CNTF genotype of 187 healthy volunteer of Korean, and compared the frequency difference in CNTF gene mutation among Korean, Japanese, and other nations or race. The number of normal homozygote was 138 (73.8%), mutant homozygote 47 (25.1%), and mutant homozygote was 2 (1.1%). The mutated allele frequency of CNTF gene in Korean was 13.6%, which was not significantly different from that of other nations or race (10~20%).