Clinical Efficacy of Recombinant Activated Factor VII in Management of Postpartum Hemorrhage / 대한주산의학회잡지
Korean Journal of Perinatology
; : 29-36, 2013.
Article
in En
| WPRIM
| ID: wpr-208960
Responsible library:
WPRO
ABSTRACT
PURPOSE: This study was aimed to investigate the clinical efficacy of recombinant activated factor VII (rFVIIa) for patients with intractable postpartum hemorrhage. METHODS: This was a retrospective study of ten patients who were treated with rFVIIa from July 2010 to February 2012 in one tertiary center. To evaluate each case, we used a standardized case record form. The primary outcome measures were response of rFVIIa, reduction of blood product requirement, changes of coagulation parameter. The response of rFVIIa was categorized to three groups: "complete responder", "partial responder", "poor responder". RESULTS: After the administration of rFVIIa, effect for bleeding was completely responded in 4 patients, partially responded in 6 patients, and poorly responded in none. A certain amount of reduction in blood product requirements was noted following rFVIIa administration, although no significant differences were observed statistically between before and after rFVIIa administration except RBC (P<0.01). Fibrinogen and INR were significantly reduced in all case types, but other coagulation parameters were not (P<0.01). CONCLUSION: The present results suggest that rFVIIa is a beneficial therapeutic option that could reduce blood loss and contribute to reduction of maternal morbidities and mortalities in patients with massive postpartum hemorrhage.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Recombinant Proteins
/
Fibrinogen
/
Factor VIIa
/
Retrospective Studies
/
Outcome Assessment, Health Care
/
International Normalized Ratio
/
Postpartum Period
/
Hemorrhage
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Postpartum Hemorrhage
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Korean Journal of Perinatology
Year:
2013
Type:
Article