Incidence and Causes of Hypereosinophilia in the Patients of a University Hospital / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 185-193, 2009.
Article
in Korean
| WPRIM
| ID: wpr-208987
ABSTRACT
BACKGROUND:
Eosinophilia may be associated with various primary and reactive conditions. The incidence and the causes of eosinophilia might have been changed according to the changes in the incidence of diseases such as cancer, chronic degenerative diseases, etc. We have conducted a retrospective study to investigate the incidence and causes of eosinophilia.METHODS:
Eosinophilia and hypereosinophilia were defined when absolute eosinophil count was greater than 500/microL and 1,500/microL, respectively. Patient's clinical records were reviewed to find out the underlying clinical conditions responsible for causes of hypereosinophilia. Conventional chromosomal analysis, reverse transcriptase PCR and FISH for gene rearrangement were performed to check the presence of clonal eosinophilia.RESULTS:
Out of 41,137 patients who had a hematology profile performed, 5,019 (12.2%) and 373 patients (0.9%) were found to have eosinophilia and hypereosinophilia, respectively. Among patients with hypereosinophilia, 227 patients (60.9%) had identifiable and/or possible causes. The major causes of hypereosinophilia were malignancy (35.2%), allergy and skin diseases (18.1%), infectious diseases (15.4%), hepatobiliary diseases (7.5%), bone marrow clonal diseases (6.6%) and parasite infections (6.6%). We also found a rare case of FIP1L1-PDGFRalpha positive chronic eosinophilic leukemia combined with light chain multiple myeloma.CONCLUSIONS:
We found a difference in the distribution of causes of hypereosinophilia in comparison with previous Korean studies, and the most common cause of hypereosinophilia in the current study was malignancy. A rare case of clonal eosinophilia (chronic eosinophilic leukemia) associated with multiple myeloma was confirmed using molecular studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow
/
Sex Factors
/
Retrospective Studies
/
Age Factors
/
Hypereosinophilic Syndrome
/
Receptor, Platelet-Derived Growth Factor alpha
/
MRNA Cleavage and Polyadenylation Factors
/
Eosinophilia
/
Hospitals, University
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Korean
Journal:
The Korean Journal of Laboratory Medicine
Year:
2009
Type:
Article
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