Persistent Anemia in a Patient with Diffuse Large B Cell Lymphoma: Pure Red Cell Aplasia Associated with Latent Epstein-Barr Virus Infection in Bone Marrow
Journal of Korean Medical Science
;
: S167-S170, 2007.
Article
in English
| WPRIM
| ID: wpr-209037
ABSTRACT
We report a case of pure red cell aplasia (PRCA), which was initially suspected as a result of bone marrow involvement of diffuse large B cell lymphoma. Persistent anemia without an obvious cause was observed in a 47-yr-old man diagnosed with relapsed diffuse large B cell lymphoma. The bone marrow study showed only erythroid hypoplasia without the evidence of bone marrow involvement with lymphoma cells, thus PRCA was suggested. However, parvovirus infection was excluded as a potential cause of PRCA because of negative IgM anti-parvovirus B19 antibody and negative parvovirus PCR in the serum. Latent Epstein-Barr virus (EBV) infection of bone marrow was suggested by in situ hybridization with EBV-encoded small RNA (EBER) that showed a strong positive expression in bone marrow cells. Thus, PRCA was thought to be associated with latent EBV infection in bone marrow cells. Although the finding of unexplained anemia is a possible predictor of bone marrow involvement with lymphoma cells, PRCA as a result of a viral infection including EBV should be considered in lymphoma patients. This is the first report of the occurrence of PRCA associated with latent EBV infection in a patient with non-Hodgkin's lymphoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow
/
Bone Marrow Diseases
/
Lymphoma, Large B-Cell, Diffuse
/
Red-Cell Aplasia, Pure
/
Bone Marrow Neoplasms
/
Epstein-Barr Virus Infections
/
Diagnosis, Differential
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2007
Type:
Article
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