A Case of Hyperkalemic Periodic Paralysis Induced by Diabetic Nephropathy / 대한내과학회지
Korean Journal of Medicine
;
: S227-S232, 2011.
Article
in Korean
| WPRIM
| ID: wpr-209153
ABSTRACT
Hyperkalemic periodic paralysis is characterized by episodic flaccid paralysis of the skeletal muscles due to an increase in serum potassium concentrations. Primary hyperkalemic periodic paralysis is caused by point mutations in SCN4A, encoding a voltage-gated skeletal muscle sodium channel. However, hyperkalemia-related diseases, such as renal failure, adrenal insufficiency, hypoaldosteronism, and chronic diuretic use, can induce secondary hyperkalemic periodic paralysis. Diagnosis of this disease is based on clinical features, nerve conduction studies, and a DNA sequence analysis. In cases of diagnostic uncertainty, a provocation test can be used to ensure the correct diagnosis. Here, we report a case of secondary hyperkalemic periodic paralysis with hyperkalemia that was induced by diabetic nephropathy, and review the relevant literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paralysis
/
Potassium
/
Hypoaldosteronism
/
Sodium Channels
/
Sequence Analysis, DNA
/
Point Mutation
/
Adrenal Insufficiency
/
Muscle, Skeletal
/
Dietary Sucrose
/
Paralysis, Hyperkalemic Periodic
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2011
Type:
Article
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