Changes in serum uric acid levels after allogeneic hematologic stem cell transplantation: A retrospective cohort study
Blood Research
;
: 200-203, 2016.
Article
in English
| WPRIM
| ID: wpr-209252
ABSTRACT
BACKGROUND:
Since cell turnover in the hematopoietic system constitutes a major source of uric acid (UA) production, we investigated whether hematopoietic stem cell transplantation (HSCT) is associated with significant changes in serum UA levels in patients with hematological disorders.METHODS:
Patients who underwent HSCT at our institution between 2001 and 2012 were retrospectively enrolled. Serum UA levels at 3 months before, 1 week before, and 3 months and 1 year after HSCT were examined.RESULTS:
Complete clinical and laboratory information including data regarding UA levels was available for 93 patients. At baseline, the mean UA level was 4.9±2.1 mg/dL, with an overall prevalence of hyperuricemia of 15% (defined as serum UA>6.8 mg/dL). Mean UA levels tended to be higher in patients with acute myeloid leukemia (4.8±2.0 mg/dL) and non-Hodgkin lymphoma (5.1±2.3 mg/dL) and lower in patients with aplastic anemia (mean, 4.2±1.8 mg/dL). UA levels dropped during myeloablative conditioning, reaching a nadir on the day of HSCT (3.27±1.4 mg/dL). Over the 3 months following HSCT, UA levels rose sharply (5.0±2.1 mg/dL) and remained stable up to 1 year after HSCT (5.5±1.6 mg/dL). UA levels in HSCT recipients at 12 months correlated with those of their respective graft donors (Pearson r=0.406, P=0.001).CONCLUSION:
HSCT is associated with significant changes in uric acid levels in patients with hematologic disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Tissue Donors
/
Uric Acid
/
Bone Marrow
/
Lymphoma, Non-Hodgkin
/
Leukemia, Myeloid, Acute
/
Prevalence
/
Retrospective Studies
/
Cohort Studies
/
Hematopoietic Stem Cell Transplantation
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Blood Research
Year:
2016
Type:
Article
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