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Treatment outcomes of IMEP as a front-line chemotherapy for patients with peripheral T-cell lymphomas
Blood Research ; : 187-192, 2016.
Article in English | WPRIM | ID: wpr-209254
ABSTRACT

BACKGROUND:

This study aimed to assess the treatment outcomes of ifosphamide, mesna, etoposide, and prednisolone (IMEP) combination regimen as a front-line chemotherapy in patients with peripheral T-cell lymphomas (PTCLs).

METHODS:

Clinical data of 38 newly diagnosed PTCLs patients who underwent IMEP at Busan Paik Hospital from January 2002 to December 2013 were retrospectively analyzed.

RESULTS:

The overall response rate was 68.5%, with 21 (55.3%) complete response/complete response unconfirmed and 6 (15.8%) partial response (PR). The median follow-up duration was 25.5 months (range, 0.2-87.3). The median overall survival was not reached and 2-year survival rate was 67%. The median progression free survival was 23 months. The most frequently reported adverse effects higher than grade 3 were hematologic toxicities including neutropenia (68.4%), thrombocytopenia (42.1%). There was no treatment-related mortality.

CONCLUSION:

IMEP regimen is effective and safe as a front-line chemotherapy in patients with PTCLs.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Thrombocytopenia / Prednisolone / Survival Rate / Retrospective Studies / Follow-Up Studies / Mortality / Lymphoma, T-Cell, Peripheral / Mesna / Disease-Free Survival / Drug Therapy Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Blood Research Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Thrombocytopenia / Prednisolone / Survival Rate / Retrospective Studies / Follow-Up Studies / Mortality / Lymphoma, T-Cell, Peripheral / Mesna / Disease-Free Survival / Drug Therapy Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Blood Research Year: 2016 Type: Article