Detection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas
Blood Research
;
: 181-186, 2016.
Article
in English
| WPRIM
| ID: wpr-209255
ABSTRACT
BACKGROUND:
Recent studies have identified a high prevalence of the MYD88 L265P mutation in lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) cases, whereas low frequencies have been observed in other B cell non-Hodgkin lymphomas (NHLs).METHODS:
We evaluated the sensitivity of the mutant enrichment 3'-modified oligonucleotide (MEMO)-PCR technique, a new detection method. We examined the MYD88 L265P mutation in a series of Korean patients with LPL/WM and other B cell NHLs in bone marrow aspirates, using the MEMO-PCR technique.RESULTS:
The sensitivity of MEMO-PCR was estimated to be approximately 10-16.7%. MYD88 L265P was detected in 21 of 28 LPL cases (75%) and only three of 69 B cell NHL cases (4.3%).CONCLUSION:
Although MEMO-PCR had relatively low sensitivity, we confirmed the high prevalence of the MYD88 L265P mutation in Korean LPL patients. Our study suggests the diagnostic value of MYD88 L265P for differentiating B-cell NHLs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bone Marrow
/
Lymphoma, Non-Hodgkin
/
B-Lymphocytes
/
Prevalence
/
Waldenstrom Macroglobulinemia
/
Lymphoma
/
Methods
Type of study:
Diagnostic study
/
Prevalence study
Limits:
Humans
Language:
English
Journal:
Blood Research
Year:
2016
Type:
Article
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