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Detection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas
Blood Research ; : 181-186, 2016.
Article in English | WPRIM | ID: wpr-209255
ABSTRACT

BACKGROUND:

Recent studies have identified a high prevalence of the MYD88 L265P mutation in lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) cases, whereas low frequencies have been observed in other B cell non-Hodgkin lymphomas (NHLs).

METHODS:

We evaluated the sensitivity of the mutant enrichment 3'-modified oligonucleotide (MEMO)-PCR technique, a new detection method. We examined the MYD88 L265P mutation in a series of Korean patients with LPL/WM and other B cell NHLs in bone marrow aspirates, using the MEMO-PCR technique.

RESULTS:

The sensitivity of MEMO-PCR was estimated to be approximately 10-16.7%. MYD88 L265P was detected in 21 of 28 LPL cases (75%) and only three of 69 B cell NHL cases (4.3%).

CONCLUSION:

Although MEMO-PCR had relatively low sensitivity, we confirmed the high prevalence of the MYD88 L265P mutation in Korean LPL patients. Our study suggests the diagnostic value of MYD88 L265P for differentiating B-cell NHLs.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Marrow / Lymphoma, Non-Hodgkin / B-Lymphocytes / Prevalence / Waldenstrom Macroglobulinemia / Lymphoma / Methods Type of study: Diagnostic study / Prevalence study Limits: Humans Language: English Journal: Blood Research Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Bone Marrow / Lymphoma, Non-Hodgkin / B-Lymphocytes / Prevalence / Waldenstrom Macroglobulinemia / Lymphoma / Methods Type of study: Diagnostic study / Prevalence study Limits: Humans Language: English Journal: Blood Research Year: 2016 Type: Article