Expression of Osteopontin and Clusterin in Transitional Cell Carcinoma of the Bladder: Comparison to the Pathologic Stage / 대한비뇨기과학회지
Korean Journal of Urology
;
: 341-346, 2005.
Article
in Korean
| WPRIM
| ID: wpr-209457
ABSTRACT
PURPOSE:
This study was performed to evaluate the expressions of osteopontin (OPN) and clusterin in a transitional cell carcinoma (TCC) of the urinary bladder, and then compare their expression rates with the tumor invasiveness. MATERIALS ANDMETHODS:
Twenty-five superficial and 25 invasive TCC were used for immunohistochemical staining.RESULTS:
All 25 non-invasive TCC showed a strong positive reaction for OPN. Twenty of the invasive TCC showed a strong positive reaction for OPN, but 5 showed only a weak positive reaction. OPN expression was significantly decreased in the invasive TCC (p=0.02). Eighteen superficial TCC showed a weak positive reaction for clusterin, with 7 showing a negative reaction. Nine invasive TCC showed a strong positive reaction for clusterin, and 11 showed only a weak positive reaction. Five invasive TCC showed a negative reaction for clusterin. Clusterin expression was significantly increased in the invasive TCC (p=0.001).CONCLUSIONS:
These results may suggest that OPN and clusterin could be used as markers to predict the biological behavior of a TCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urinary Bladder
/
Carcinoma, Transitional Cell
/
Clusterin
/
Osteopontin
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2005
Type:
Article
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