In situ tissue regeneration through host stem cell recruitment
Experimental & Molecular Medicine
;
: e57-2013.
Article
in English
| WPRIM
| ID: wpr-209544
ABSTRACT
The field of tissue engineering has made steady progress in translating various tissue applications. Although the classical tissue engineering strategy, which involves the use of culture-expanded cells and scaffolds to produce a tissue construct for implantation, has been validated, this approach involves extensive cell expansion steps, requiring a lot of time and laborious effort before implantation. To bypass this ex vivo process, a new approach has been introduced. In situ tissue regeneration utilizes the body's own regenerating capacity by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the site of injury. This approach relies on development of a target-specific biomaterial scaffolding system that can effectively control the host microenvironment and mobilize host stem/progenitor cells to target tissues. An appropriate microenvironment provided by implanted scaffolds would facilitate recruitment of host cells that can be guided to regenerating structural and functional tissues.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Tissue Engineering
/
Stem Cell Transplantation
/
Guided Tissue Regeneration
/
Tissue Scaffolds
Limits:
Animals
/
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2013
Type:
Article
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