A Case of Nasu-Hakola Disease without Fractures or Consanguinity Diagnosed Using Exome Sequencing and Treated with Sodium Valproate
Clinical Psychopharmacology and Neuroscience
;
: 324-326, 2015.
Article
in English
| WPRIM
| ID: wpr-209617
ABSTRACT
Nasu-Hakola disease (NHD) is a rare autosomal recessive neuropsychiatric disorder characterized by bone cysts, fractures, and cognitive impairment. Two genes are responsible for the development of NHD; TYROBP and TREM2. Although it presents with typical signs and symptoms, diagnosing this disease remains difficult. This case report describes a male with NHD with no family or past history of bone fractures who was diagnosed using exome sequencing. His frontal lobe psychiatric symptoms recovered partially following treatment with sodium valproate, but not with an antipsychotic.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sodium
/
Bone Cysts
/
Valproic Acid
/
Consanguinity
/
Fractures, Bone
/
Exome
/
Frontal Lobe
Type of study:
Diagnostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2015
Type:
Article
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