A Comparisons of Remifentanil versus Alfentanil-based Total Intravenous Anesthesia (TIVA) for Oocyte Retrieval / 대한마취과학회지

ABSTRACT

BACKGROUND: This prospective, randomized, double-blind study was carried out to compare the effect of remifentanil with that of alfentanil, as a part of total intravenous anesthesia (TIVA) on the hemodynamic profile, recovery characteristics, visual analogue scale (VAS) for postoperative pain, and serum cortisol changes in the patients undergoing oocyte retrieval. METHODS: The patients were assigned to receive either propofol-remifentanil (n = 31) or propofol-alfentanil (n = 30). When the target propofol concentration (3.0microgram/ml) was reached, the study drugs were administered over a 60 s period with the loading dose (either remifentanil 1microgram/kg or alfentanil 10microgram/kg) and were maintained with a continuous infusion (either remifentanil 0.08microgram/kg/min or alfentanil 0.4microgram/kg/min). The propofol requirements, blood pressure, pulse rate, serum cortisol, VAS scores for pain, recovery profile and postoperative side effect were recorded in both the operating and recovery rooms. RESULTS: There were significant differences in the VAS score for postoperative pain 30 minutes after oocyte retrieval between the two groups. CONCLUSIONS: The propofol-remifentanil and propofol-alfe ntanil techniques are suitable for oocyte retrieval but the propofol-remifentanil technique requires additional analgesics for postoperative pain due to the rapid offset of remifentanil.