The Effect of 6% Hydroxyethyl Starch 130/0.4 on Hemostasis and Hemodynamic Efficacy in Off-pump Coronary Artery Bypass Surgery: a Comparison with 6% Hydroxyethyl Starch 200/0.5 / 대한마취과학회지
Korean Journal of Anesthesiology
;
: S14-S21, 2007.
Article
in English
| WPRIM
| ID: wpr-209759
ABSTRACT
BACKGROUND:
This study was designed to compare the effect of low-molecular 6% hydroxyethyl starch (HES) 130/0.4 on hemostasis and hemodynamic efficacy with that of medium-molecular 6% HES 200/0.5 in patients undergoing off-pump coronary artery bypass surgery.METHODS:
Forty-eight patients were randomized to receive up to 33 ml/kg of either 6% HES 130/0.4 or 6% HES 200/0.5. Hemodynamic variables and blood tests including thromboelastography were measured 10 min after induction (baseline value, T0), 5 min after acute loading of HES 10 ml/kg (T1) in hypovolemic patients, after sternum closure (T2), and 16 hr after intensive care unit (ICU) arrival (T3). Chest tube drainage was recorded until 16 hours after ICU arrival.RESULTS:
Hemodynamic variables were similar in both groups. Chest tube drainage at 16 hr after surgery was higher in HES 200/0.5 group than that in HES 130/0.4 group. Maximum clot firmness was decreased in HES 200/0.5 group at sternal closure but not in HES 130/0.4 group.CONCLUSIONS:
Both HES 200/0.5 and HES 130/0.4 were equally efficient in maintaining stable hemodynamics during off-pump coronary artery bypass surgery. However, HES 130/0.4 may reduce postoperative blood loss compared to that of HES 200/0.5 at the same dose of 33 ml/kg.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Starch
/
Sternum
/
Thrombelastography
/
Blood Coagulation
/
Chest Tubes
/
Drainage
/
Postoperative Hemorrhage
/
Hypovolemia
/
Coronary Artery Bypass, Off-Pump
/
Fluid Therapy
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article
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