Impact of Intravesical Protrusion of the Prostate in the Treatment of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia of Moderate Size by Alpha Receptor Antagonist / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: 187-190, 2012.
Article
in English
| WPRIM
| ID: wpr-209788
ABSTRACT
PURPOSE:
To evaluate whether intravesical protrusion of the prostate (IPP) is related to the treatment effect of alpha-1 receptor antagonist in patients with lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) with a prostate size of less than 40 g.METHODS:
A total of 77 BPH patients over 50 years of age treated with alfuzosin (alpha blocker) were enrolled prospectively. The study included only patients with BPH of 40 g or less. The patients were classified into two groups depending on the presence of IPP at baseline the IPP group (41 patients) and the non-IPP group (36 patients). Prostate volume, prostate-specific antigen (PSA), International Prostate Symptom Score and quality of life (IPSS/QoL), maximum flow rate (Qmax), and postvoid residual (PVR) volume were compared between the groups. The clinical significance of IPP was evaluated after the patients had been taking alfuzosin for 8 weeks.RESULTS:
PSA and IPSS (total and voiding subscore) showed significant correlations with IPP (P<0.05). Comparison of parameters before and after 8 weeks showed that alfuzosin improved the total IPSS and all subscores (P<0.001), QoL (P<0.001), Qmax (P<0.001), and PVR (P=0.030) in the non-IPP group.CONCLUSIONS:
Alfuzosin may be less effective in improving symptom scores, PVR, and Qmax in the treatment of LUTS/BPH in the presence of IPP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Quality of Life
/
Quinazolines
/
Urinary Tract
/
Urinary Bladder Neck Obstruction
/
Prospective Studies
/
Prostate-Specific Antigen
/
Adrenergic alpha-1 Receptor Antagonists
/
Lower Urinary Tract Symptoms
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Language:
English
Journal:
International Neurourology Journal
Year:
2012
Type:
Article
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