A Novel PA-X Protein Translated from Influenza A Virus Segment 3
Journal of Bacteriology and Virology
;
: 368-371, 2012.
Article
in Korean
| WPRIM
| ID: wpr-209793
ABSTRACT
The pathogenicity of influenza A viruses is a multigenic trait, which is orchestrated by the global networks between eight viral genomic constituents and their cellular interacting partners. A recent report provided information on the finding of a new PA ribosomal frameshifting product, the PA-X protein, in the influenza A virus segment 3, and an endonuclease property was suggested for a possible role of the PA-X protein. In cultured cells, viral growth was not affected by the PA-X protein expression. However, the reduced pathogenicity of mice appeared to be closely associated with the PA-X protein expression. It was also revealed that the PA-X protein was able to modulate host gene expression. Considered together, the PA-X protein can be a cellular signaling modulator and subsequently control viral pathogenicity. By reviewing recent publications, we present new insights in the contribution of the PA-X protein to the cellular signaling network and the resultant viral pathogenicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Influenza A virus
/
Gene Expression
/
Cells, Cultured
/
Frameshifting, Ribosomal
/
Influenza, Human
Limits:
Animals
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2012
Type:
Article
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