Factors Associated with Progression of Visual Field Defect in Normal Tension Glaucoma

ABSTRACT

PURPOSE: To evaluate the risk factors associated with progression of visual field defect in patients with normal-tension glaucoma (NTG). METHODS: We reviewed medical records of 61 patients who were diagnosed as NTG and followed for more than 2 years. Age, sex, family history of glaucoma, migraine, hypertension, diabetes mellitus, refractive error, baseline intraocular pressure (IOP), disc hemorrhage, topographic data of optic disc, MD (mean deviation), and CPSD (corrected pattern standard deviation) of visual field test were analyzed. Progression of visual field was determined by Change Probability Analysis of Humphrey Field Analyzer. RESULTS: During an average follow-up of 42.5 months, 11 eyes of 61 eyes (18%) showed progression of visual field defect. Higher baseline IOP influenced significantly on the progression of visual field defect in NTG patients (Cox regression analysis, p<0.05). CONCLUSIONS: The higher the baseline IOP, the higher the probability of visual field progression.