Bedside-Friendly Prediction for Presence of Post-Myocardial lnfarction Systolic Dysfunction Using Multimarker Panel: Integrating Salivary Diagnostics into Clinical Practice
Korean Circulation Journal
;
: 246-254, 2013.
Article
in English
| WPRIM
| ID: wpr-209908
ABSTRACT
BACKGROUND AND OBJECTIVES:
We investigated if a combination of plasma or salivary interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and troponin can improve estimation of the pretest probability of the left ventricular systolic dysfunction (LVSD). SUBJECTS ANDMETHODS:
Eighty patients with newly-diagnosed myocardial infarction (MI) were echocardiographically examined for LVSD (ejection fraction < or =40%). Measurements included traditional MI risk factors, plasma and salivary concentrations of troponin, IL-2, IL-6, TNF-alpha, and TGF-beta. With the LVSD as the outcome variable, we developed logistic regression models, starting with a basic model incorporating traditional risk factors and consecutively adding salivary and plasma biomarkers. Models were compared using several criteria, including (but not limited to) C statistic (discrimination) and net reclassification improvement index (NRI).RESULTS:
Apart from troponin, plasma, and salivary values of the biomarkers were correlated spearman's rho was 0.19 (p=0.088) for troponin, 0.36 (p=0.001) for IL-2, 0.74 (p<0.001) for IL-6, 0.61 (p<0.001) for TNF-alpha, and 0.65 (p<0.001) for TGF-beta. The predictive performances of the basic model for estimating the pretest probability of the presence of LVSD considerably improved when cytokines were added (salivary added C-statistic from 0.77 to 0.82 and NRI 77%; plasma added C-statistic to 0.80 and NRI 134%).CONCLUSION:
Multiple biomarkers added diagnostic value to the standard risk factors for predicting the presence of post-MI LVSD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Saliva
/
Troponin
/
Biomarkers
/
Logistic Models
/
Risk Factors
/
Cytokines
/
Transforming Growth Factor beta
/
Interleukins
/
Interleukin-6
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2013
Type:
Article
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