High-normal Glucose Levels in Non-diabetic and Pre-diabetic Men Are Associated with Decreased Testosterone Levels / 가정의학회지
Korean Journal of Family Medicine
;
: 152-156, 2012.
Article
in English
| WPRIM
| ID: wpr-20996
ABSTRACT
BACKGROUND:
Testosterone levels are decreased in diabetic patients and recent studies have suggested that high-normal fasting glucose is a risk factor for cardiovascular disease. To further elucidate the relationship between plasma glucose and testosterone, we investigated the association between fasting plasma glucose (FPG) and endogenous sex hormones (serum total testosterone, sex hormone binding globulin, estradiol, and the ratio of testosterone to estradiol) in non-diabetic and pre-diabetic men.METHODS:
This study included 388 men (age > or = 40 years) who visited the health promotion center of a university hospital from May 2007 to August 2008. The subjects were divided into quartiles based on their FPG levels and correlation and multiple linear regression analyses were performed. Q1 (65 mg/dL or = 88 mg/dL) had significantly decreased testosterone levels when compared with subjects in the normal FPG group (Q1 with FPG < 88 mg/dL, P < 0.005). Sex hormone binding globulin, estradiol and the ratio of testosterone to estradiol were not correlated with FPG.CONCLUSION:
Our study indicates that high-normal fasting glucose levels are associated with decreased testosterone levels in non-diabetic and pre-diabetic men.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Gonadal Steroid Hormones
/
Smoke
/
Testosterone
/
Alcohol Drinking
/
Sex Hormone-Binding Globulin
/
Cardiovascular Diseases
/
Smoking
/
Body Mass Index
/
Linear Models
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Korean Journal of Family Medicine
Year:
2012
Type:
Article
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