Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress
Biomolecules & Therapeutics
;
: 616-622, 2016.
Article
in English
| WPRIM
| ID: wpr-209971
ABSTRACT
Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) radiation in a human keratinocyte cell line (HaCaT). Baicalein absorbed light within the wavelength range of UVB. In addition, baicalein decreased the level of intracellular reactive oxygen species (ROS) in response to UVB radiation. Baicalein protected cells against UVB radiation-induced DNA breaks, 8-isoprostane generation and protein modification in HaCaT cells. Furthermore, baicalein suppressed the apoptotic cell death by UVB radiation. These findings suggest that baicalein protected HaCaT cells against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging ROS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Keratinocytes
/
Cell Line
/
Cell Death
/
Reactive Oxygen Species
/
Apoptosis
/
Oxidative Stress
/
Scutellaria baicalensis
/
DNA Breaks
Limits:
Humans
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2016
Type:
Article
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